Ultrafast Lasers/Bioimaging: Ultrafast laser pulses enable promising new x-ray imaging

Oct. 13, 2015
A method based on ultrafast laser-generated x-rays has proven able to generate 3D images of ultrafine structures in the body of a living organism for the first time.  
(Image: Karsch/Pfeiffer)
An ultrafast laser-based x-ray tomography method enabled creation of the roughly 1500 individual images that make up this rendering. The extremely fine structures appearing in 3D would be invisible in a conventional x-ray image.
An ultrafast laser-based x-ray tomography method enabled creation of the roughly 1500 individual images that make up this rendering. The extremely fine structures appearing in 3D would be invisible in a conventional x-ray image.

A method based on ultrafast laser-generated x-rays has proven able to generate 3D images of ultrafine structures in the body of a living organism for the first time. The approach could make future medical applications more cost-effective and space-efficient.1

The development includes German researchers from Ludwig-Maximilians University, the Max Planck Institute of Quantum Optics, and Technical University of Munich (TUM). With laser light, researchers from the Laboratory of Attosecond Physics at Max Planck Institute and TUM built a miniature x-ray source able to capture ultrafine details. When physicists Prof. Stefan Karsch and Prof. Franz Pfeiffer illuminated a tiny fly with x-rays, they were able to image the finest hairs on its wings. Coupling the laser-generated x-ray technique with phase-contrast x-ray tomography enabled a 3D view.

The x-rays required for this approach are generated by electrons accelerated to nearly the speed of light over a distance of approximately 1 cm—by laser pulses of ~25 fs with a power of approximately 80 TW. Until now, such radiation could be produced only in enormous, expensive ring accelerators.

Because the technology can distinguish differences in tissue density, it is particularly interesting for medical applications: Cancer tissue, for example, is less dense than healthy tissue. If the researchers are able to shorten the wavelength of the x-rays to penetrate thicker tissue, the method could enable very early cancer detection by imaging tumors less than 1 mm in diameter.

1. J. Wenz et al., NatureCommun., 6, 7568 (2015); doi:10.1038/ncomms8568.

About the Author

Barbara Gefvert | Editor-in-Chief, BioOptics World (2008-2020)

Barbara G. Gefvert has been a science and technology editor and writer since 1987, and served as editor in chief on multiple publications, including Sensors magazine for nearly a decade.

Sponsored Recommendations

Achromatic Lenses: High-Quality Custom Optics

March 13, 2025
Ensure clarity and accuracy in your optics systems with Lacroix’s achromatic lenses. Explore how our custom solutions minimize chromatic aberration for perfect results.

Manufacturing Considerations for Tolerancing Aspheres

March 13, 2025
Understand the critical factors in manufacturing aspheres and how Lacroix Optics ensures precise tolerancing in every optical component.

Explore Our Videos: Insights into Precision Optics

March 13, 2025
Get an inside look at Lacroix Optics with our collection of informative videos showcasing our capabilities, innovations, and processes.

Optical Assemblies: Reliable and Precise Solutions

March 13, 2025
Ensure your optical system works seamlessly with Lacroix Optics' custom optical assemblies. Discover the precision and reliability we bring to every project.

Voice your opinion!

To join the conversation, and become an exclusive member of Laser Focus World, create an account today!