HORIBA Scientific Validates the HORIBA Aqualog® Performance for Pharmaceutical and Industrial Analyses
October 4, 2021 – Piscataway, NJ HORIBA Scientific, a global leader in the production of high-performance spectroscopy systems and solutions, announces it has validated the HORIBA Aqualog® spectrofluorometer’s performance for pharmaceutical and industrial analyses.
A new note explains how HORIBA's Aqualog absorbance and fluorescence performance parameters are validated using certified NIST-traceable criteria to support compliance with respective United States Pharmacopoeia (USP) chapter guidelines.
The Aqualog is fully supported for pharmaceutical and industrial installations with a comprehensive IQ/OQ document and protocol. The IQ/OQ takes into consideration all instrument performance certifications and software functionalities associated with 21 CFR Chapter 11 compliance, as required for current Good Manufacturing Practices.
The Aqualog uses A-TEEM technology, simultaneous Absorbance-Transmission fluorescence Excitation and Emission Matrix acquisition. It is a fast and inexpensive optical technique for quantitative molecular fingerprinting.
With the Aqualog, HORIBA Scientific has created a new analytical instrument that provides quantitative molecular profiling with real-time Inner Filter Effect correction (IFE). The patented configuration of the Aqualog CCD spectrometer quickly acquires 3D fluorescence Excitation Emission Matrices (EEMs) simultaneously with the UV-VIS absorbance spectrum.
IFE correction is important because it facilitates a wider linear concentration range for fluorescence spectral component information, which is important for component identification and quantification when employing uni - or multivariate analyses commonly applied in pharmaceutical and other life science industries.
The combined fluorescence/absorbance acquisition platform has a clear path to traceable validation, following standard established protocols for each. This includes certified validation of all major absorbance and fluorescence performance specifications consistent with the US Pharmacopoeia methods, namely, USP<857> and <853>, respectively (which are part of USP 40) published guidelines.
The fluorescence spectral emission for the Aqualog is both corrected and certified using Standard Reference Materials sourced directly from NIST, namely SRMs 2940, 2942 and 2943.
For more information, and to download the brochure, please go to: www.horiba.link/aqualog-pharma
About HORIBA Scientific
HORIBA Scientific, part of HORIBA Instruments Incorporated, headquartered in the United States, provides an extensive array of instruments and solutions for applications across a broad range of scientific R&D and QC measurements. HORIBA Scientific is a world leader in OEM Spectroscopy, elemental analysis, fluorescence (including the PTI brand), forensics, GDS, ICP, particle characterization, Raman, spectroscopic ellipsometry, sulfur-in-oil, SPRi and water quality measurements, as well as XRF.
Our instruments are found in universities and industries around the world. Proven quality and trusted performance have established widespread confidence in the HORIBA Brand. HORIBA supplies over 500 types of scientific analyzers to universities, research institutions, various manufacturing industries and the government. In some of the most advanced science and technologies, HORIBA provides multi-faceted data solutions for what are niche markets – assisting the most cutting-edge research in the tackling of uncharted territories.
Building on a long tradition of pursuing innovative technology to advance scientific efforts, HORIBA Instruments Incorporated owns various technologies that had been acquired through M&A such as Société Générale d’Optique (1969), SPEX (1988), Dilor (1995), SOFIE (1996), Jobin Yvon (1997), IBH (2003), GenOptics (2009), and Photon Technology International (2014).
The HORIBA Group is a global company that offers solutions and engineering services, based on our strong performance in developing and manufacturing instruments and products in the analysis and measurement fields. With “Explore the Future” as its brand message, HORIBA has been pursuing state-of-the-art analysis and measurement technology since its establishment in 1953. Founded in the historic city of Kyoto, Japan, it has grown steadily throughout its 68 years of establishment and is now providing services worldwide as the leader in the analysis technology field. We engage in five different business segments with high value-added products and services: Automotive, Medical-Diagnostic, Semiconductor, Scientific, and Process & Environmental. We have established an optimal number of business bases in Japan, Asia, Europe, and the Americas.