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    • Robert Alfano

    Robert Alfano is a distinguished professor of science and engineering at the City College of the City University of New York (CUNY), where he is the director of Institute for Ultrafast Spectroscopy and Lasers. He works primarily in the field of biomedical imaging and spectroscopy, and is known for discovering the white light supercontinuum laser. He has published more than 700 papers in referred journals and has over 100 patents, and has won numerous awards including the SPIE’s inaugural Britton Chance Biomedical Optics Award.

    FIGURE 1. Optical processes involved in Raman scattering and other light-tissue interactions are compared.1
    Spectroscopy

    Spectroscopy/Oncology/Optical Biopsy: Visible resonance Raman improves tumor identification and grading

    Yan Zhou
    Oct. 1, 2019
    A novel application of visible resonance Raman (VRR) spectroscopy demonstrates potential to impact outcomes for glioma patients.
    FIGURE 1. Average S3 of cancerous (solid) and normal (dash) breast tissues acquired by the selective Δλi = 40 nm: The salient difference of S3 between cancerous and normal breast tissues can be observed as two reverses of the peak intensities at ~294 and ~340 nm, and a tiny peak is evident at 385 nm for the cancerous tissue.
    Research

    SPECTROSCOPY: Cancer detection using Stokes shift spectroscopy

    Yang Pu
    Sept. 16, 2013
    Research demonstrates that—and explains why—Stokes shift spectroscopy (S3) is superior to other spectroscopic techniques for recognizing the spectral fingerprints of biomolecules...
    FIGURE 1. Smart dye makes cancer cells glow by conjugating to a probing ligand such as an antibody, aptamer, or peptide.
    Fluorescence

    CANCER DETECTION/FLUORESCENCE IMAGING: 'Smart beacons' target cancer tumors

    Yang Pu
    July 17, 2013
    A major challenge in optical screening of cancer is to locate tumors deep within organs. "Smart" contrast agents -- along with novel, efficient optical tomography instrumentation...