Samuel Achilefu

Samuel Achilefu is director of the Optical Radiology Laboratory and a professor in the Department of Radiology at the Washington University School of Medicine (St. Louis, MO).

FIGURE 1. Smart dye makes cancer cells glow by conjugating to a probing ligand such as an antibody, aptamer, or peptide.
Fluorescence

CANCER DETECTION/FLUORESCENCE IMAGING: 'Smart beacons' target cancer tumors

July 17, 2013
A major challenge in optical screening of cancer is to locate tumors deep within organs. "Smart" contrast agents -- along with novel, efficient optical tomography instrumentation...
FIGURE 1: A tumor-induced integrin expression is imaged using a receptor-targeted NIR fluorescent molecular probe. Heterogeneity of tumor tissue is highlighted by hot regions (red color) in a magnified image of the tumor. These hot spots correlate with increase in mitochondrial NADH, suggesting highly metabolic regions of the tumor. Uptake in excretion organs (liver and kidneys) is evident [10].
Fluorescence

MOLECULAR IMAGING/FLUORESCENCE/CANCER PATHOLOGY: Unraveling the basis of disease with NIR molecular probes

Jan. 1, 2011
Molecular imaging of the expression of aberrant genes and disease biomarkers is enhanced by the use of fluorescent molecular probes. However, the plethora of imaging agents available...