Lingyan Shi

Dr. Lingyan Shi is currently an Associate Professor in the Shu Chien-Gene Lay Department of Bioengineering at UC San Diego. Her research focuses on developing high resolution optical spectroscopy and imaging platforms, and its applications for studying metabolic dynamics in aging and diseases. She discovered the “Golden Window” for deep tissue imaging and developed bioorthogonal metabolic imaging platforms that combine deuterium probing and stimulated Raman scattering (DO-SRS using heavy water and STRIDE with D-glucose) for visualizing metabolic activities in situ. The Shi group transformed SRS into a super resolution microscopy with chemical selectivity by developing Adam optimization-based Pointillism Deconvolution (A-PoD) methods. Dr. Shi holds six awarded patents. She won the Blavatnik Regional Award for Young Scientist in 2018; the Hellman Fellowship Award 2021; the “Rising Star Award” by Laser Focus World, and the “Rising Star Award” by Nature Light Science & Applications in 2021; the “Advancing Bioimaging Scialog Fellow” by RCSA and the Chan Zuckerberg Initiative in 2021, 2022, and 2023; and the Sloan Research Fellow Award in Chemistry 2023.

Dr. Shi has been mentoring graduate and undergraduate students to help them achieve excellence in academic work and become successful engineers and scientists. She plans to continue making additional contributions by enhancing more participation of underrepresented groups from the UC San Diego communities. She has been teaching core undergraduate and graduate courses in the Shu Chien-Gene Lay Department of Bioengineering at the UC San Diego Jacobs School of Engineering.