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    (Image credit: Wei Wei and Mei Xueting)
    Depiction of the adaptive sampling scheme, in which a laser beam patterned by a digital micromirror device selectively illuminates neurons and their activity in brain tissue.
    (Image credit: A. Stevens et al., Bioeng. Transl. Med.; https://doi.org/10.1002/btm2.10727)
    H&E staining on rat brain coronal slices from all treatment conditions at three days post-injury and four weeks post-injury. Images were taken from frontal cortex, corpus callosum, and choroid plexus (body of the lateral ventricle).
    (Image credit: IN-VISION Technologies)
    FIGURE 3. 4D image of a dividing cell that was detected by Aivia in a feedback loop with LAS X from Leica Microsystems.
    (Courtesy of Gowerlabs)
    FIGURE 1. The researchers use LUMO, a wearable, portable, high-density functional NIR imaging device equipped with modular tiles with built-in NIR light sources and detectors.
    (Image credit: Lingjie Kong)
    FIGURE 1. Schematic of neurochemical sensing in vivo with FOPECs.

    Highlights

    (Courtesy of J. Chen et al., Nat. Methods; doi:10.1038/s41592-023-01820-3)
    FIGURE 1. An optomechanical design of the SMURF two-photon microscope.
    Bio&Life Sciences

    A brain imaging trifecta

    Justine Murphy
    July 13, 2023
    An approach to imaging electrical activity deep in the brain makes neurological studies more effective and less invasive.
    (Courtesy of Anna Maria Reuss, Fabian Voigt)
    Detailed image of neurons in a mouse brain, as captured using the Schmidt objectives.
    Bio&Life Sciences

    Schmidt telescope, scallop eyes transform microscope objectives

    Justine Murphy
    May 22, 2023
    Drawing inspiration from the uniqueness of scallop eyes, neuroscientists in Switzerland have developed microscope objectives that could make imaging samples simpler, cheaper, ...
    (Courtesy of Ian Shih, UNC School of Medicine)
    FIGURE 1. The experimental fMRI-fiber photometry platform could offer a deeper understanding of the dynamic properties of brain states and their relationship to behaviors.
    Bio&Life Sciences

    Spectrally resolved fiber photometry system enables exploring the brain’s networks

    Justine Murphy
    April 24, 2023
    An optical fiber-based platform may lead to brain network-based treatment regimens for neuropsychiatric and neurological disorders.
    (Courtesy of Salk Institute)
    Salk researchers developed two wearable microscopes to image cellular activity in previously inaccessible regions of the spinal cord of moving mice in real time.
    Bio&Life Sciences

    Wearable microscopes help image cellular activity in spinal cords of on-the-move mice

    Justine Murphy
    April 5, 2023
    Two tiny wearable microscopes for mice are generating high-resolution, high-contrast, multicolor images in real time—providing insight into signaling patterns within spinal cords...
    (Courtesy of Osaka Metropolitan University)
    A new system allows researchers to control a nematode worm with light-sensitive proteins (opsins) triggered by white, UV, and green.
    Bio&Life Sciences

    Controlling nematode behavior with light

    Justine Murphy
    Jan. 18, 2023
    A new optogenetics-based system using various wavelengths of light is poised to significantly accelerate bio-related research.

    Recommended

    (Courtesy of Abraham Beyene, Howard Hughes Medical Institute Janelia Research Campus)
    A schematic of DopaFilm shows spatially resolved hotspots of activity (top) and DopaFilm’s fluorescent nanosensors glow brighter when exposed to dopamine (bottom).
    Bio&Life Sciences

    Material made of fluorescent nanosensors may boost neural discoveries

    Justine Murphy
    Oct. 26, 2022
    By measuring the release of dopamine and other neurotransmitters, a composite material can help provide a better understanding of chemical neurotransmission.
    Ip Rgc Stained900px
    Microscopy

    Two-photon imaging helps make discovery about light-sensitive cells in baby's retina

    Nov. 27, 2019
    A combination of techniques, including two-photon imaging, found that these light-sensitive cells communicate as part of an interconnected network that gives the retina more light...
    217254 Web
    Neuroscience

    Tapered optical probe helps detect light in the brain

    Nov. 19, 2019
    The new method allows the simultaneous collection of signals from various brain regions through the use of a tapered optical probe.
    213584 Web
    Neuroscience

    Optical nanoprobes could have use in monitoring neural activity

    Oct. 24, 2019
    The nanoprobes could show how neural circuits function at an unprecedented scale by monitoring large numbers of individual neurons simultaneously.
    0923 Alzheimers 1 Web
    Fluorescence

    Fluorescence monitors how protein aggregate present in Alzheimer's grows

    Sept. 30, 2019
    Using a fluorescence method, researchers have found a way to track the formation of soluble amyloid beta peptide aggregates implicated in the onset of Alzheimer's disease.