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  • Volume 6, Issue 4
  • Volume 6, Issue 4

    Finger Leather
    Fluorescence

    Photoacoustic device tracks ocean warming's impact on coral species

    July 17, 2013
    Many coral species, which are key for sustaining tourism, fishing, and human activity, may not survive beyond the end of this century due to ocean warming and acidification.
    Image courtesy of Rhoda Baer, National Eye Institute
    National Eye Institute scientists observe ocular tissue samples under a laser scanning microscope.
    Microscopy

    LIFE SCIENCES FUNDING/PUBLIC POLICY/BIOPHOTONICS: Biophotonics and 'the sequester'

    July 17, 2013
    How will the United States' fiscal struggles impact biophotonics development and the life sciences driven by these technologies?
    1307bowjaisaitisf1
    Microscopy

    3D OPTICAL IMAGING/SINGLE-MOLECULE LOCALIZATION MICROSCOPY: Extreme precision in 3D: Adaptive optics boosts super-resolution microscopy

    July 17, 2013
    Designed to expand the utility of super-resolution optical imaging methods PALM and STORM, a new adaptive optics approach enables the localization of a single emitter in all three...
    (Image courtesy of BaySpec)
    FIGURE 1. BaySpec's Nomadic confocal Raman microscope (a) is simultaneously equipped with three excitation sources from the visible to near-infrared: 532, 785, and 1064 nm. This system provides chemical analysis and classification. In a forensics application (b), for example, Nomadic's 1064-Raman system can map black ink on paper because inks are highly fluorescent.
    Fluorescence

    RAMAN SPECTROSCOPY/IMAGING: Life sciences picks up Raman's good vibrations

    July 17, 2013
    Advanced excitation and detection methods enable exploration of more molecular biology with Raman.
    FIGURE 1. Smart dye makes cancer cells glow by conjugating to a probing ligand such as an antibody, aptamer, or peptide.
    Fluorescence

    CANCER DETECTION/FLUORESCENCE IMAGING: 'Smart beacons' target cancer tumors

    July 17, 2013
    A major challenge in optical screening of cancer is to locate tumors deep within organs. "Smart" contrast agents -- along with novel, efficient optical tomography instrumentation...

    More content from Volume 6, Issue 4

    FIGURE 1. (a) The VCSEL is fabricated using semiconductor processing techniques (b) on wafers yielding many (c) single VCSEL devices. (d) Traditional OCT swept-source technologies tune many laser modes under the tunable filter envelope. (e) The VCSEL differs from previous technologies in that it tunes a single longitudinal mode. (F) A comparison of OCT technologies shows that the VCSEL does not lose appreciable imaging sensitivity over a 12 mm imaging range while previous technologies show significant sensitivity loss over only a few millimeters. (g) The VCSEL can be operated to achieve a 1.5 m OCT imaging range at high imaging speeds, much longer than previous OCT technologies.
    Optical Coherence Tomography

    OPTICAL COHERENCE TOMOGRAPHY/LIGHT SOURCES: Improved OCT imaging with VCSEL technology

    July 17, 2013
    Light sources based on vertical cavity surface-emitting laser (VCSEL) technology enable optical coherence tomography (OCT) to achieve long imaging range, high speed, and flexibility...
    1307bow News Fig4
    Fluorescence

    BIOPHOTONICS: LASER World of Photonics dedicates opening plenary -- and more -- to bio

    July 17, 2013
    Biophotonics was a major theme at this 40th anniversary edition of the biennial mega-event LASER World of Photonics trade fair and World of Photonics Congress (May 13-16, 2013...
    The U.S.'s National Photonics Initiative, a collaboration involving five industry associations, has an equal number of working groups, including one dedicated to health and medicine.
    Microscopy

    BIOPHOTONICS/GLOBAL COMPETITIVENESS: National, multinational efforts target biophotonics leadership

    July 17, 2013
    Although the United States currently leads the world in biophotonics, other nations are making significant investments -- and as a result, the country has lost substantial global...
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    Bioimaging

    NANOTECHNOLOGY/DRUG DELIVERY: Light-based approach creates nanostructures with drug-delivery potential

    July 17, 2013
    By shining light of various colors through a nanoscale synthetic-polymer sphere, researchers have fashioned volcano-shaped nanostructures able to store precise amounts of other...
    1307bow Break Fig6
    Bioimaging

    BIOMEDICAL IMAGING/IMAGE PROCESSING: Algorithms enable precision image thresholding, 700x speed magnification

    July 17, 2013
    For her PhD thesis, Aránzazu Jurío-Munárriz, a graduate student in computer engineering at the NUP/UPNA-Public University of Navarre in Spain, has improved two of the algorithms...
    1307bow Break Fig3
    Bioimaging

    MOBILE MEDICINE/PORTABLE INSTRUMENTATION: Optics-endowed smartphone cradle and app generate lab-quality results for a fraction of the cost

    July 17, 2013
    An iPhone app and an optics-rich smartphone cradle are enabling sensitive yet inexpensive biosensing of toxins, proteins, bacteria, viruses, and other molecules.
    1307bow Break Fig1
    Fluorescence

    FLUORESCENT PROBES/NEUROSCIENCE: Fluorescing live synapses shed light on learning, memory formation

    July 17, 2013
    A new type of imaging probe is enabling real-time visualization of excitatory and inhibitory synapses that change as new memories are formed.
    1307bowbreakf2
    Optical Coherence Tomography

    OPTICAL COHERENCE TOMOGRAPHY: High-performance SD-OCT improves depth and speed for ophthalmic imaging

    July 17, 2013
    Research in optical coherence tomography (OCT) technology has recently focused on development of ultrafast (>100 kHz A-line rate) Fourier domain OCT (FD-OCT).
    Barbaragoode2
    Biomedicine

    Weathering the new device-tax storm

    July 17, 2013
    In a Market Focus session titled Medical and Aesthetic Lasers - the Future of Light-Tissue Interaction, presentations at OSA's Conference on Lasers and Electro-Optics (CLEO) 2013...