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  • Volume 6, Issue 3
  • Volume 6, Issue 3

    Images of a lily's anther (top) and a pinecone (right) at 100x magnification captured with the LegoScope.
    Microscopy

    An optical microscope so fun and intuitive, a kid could use it

    May 1, 2013
    Three University of California San Francisco (UCSF) researchers had a vision: to find a way to make optical microscopes much easier to understand and more fun to use, particularly...
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    Fluorescence

    FLUORESCENCE IMAGING/ NANOPARTICLE TRACKING ANALYSIS: Fluorescent labeling 101

    May 1, 2013
    Fluorescence is a key tool for life sciences imaging. A few basics and tips may help to improve your results with nanoparticle tracking analysis, microscopy, or cytometry.
    FIGURE 1. OCT meets an unmet need in terms of both resolution and imaging depth for esophageal assessment. It fills a gap between endoscopic ultrasound (EUS) and confocal laser endomicroscopy.
    Optical Coherence Tomography

    OPTICAL COHERENCE TOMOGRAPHY/GASTROENTEROLOGY: Advanced OCT: Next-gen OCT for the esophagus

    May 1, 2013
    Having already revolutionized ophthalmology, optical coherence tomography (OCT) is about to be introduced to the field of gastroenterology. The approach provides noninvasive and...
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    Microscopy

    COMPUTATIONAL MICROSCOPY/ LENS-FREE IMAGING/POINT-OF-CARE DIAGNOSTICS: Algorithms and cell phone add-on enable powerful, inexpensive microscopy

    May 1, 2013
    The optical components of a modern microscope are relatively bulky and and complex...unless you replace them with digital holography, and the microscope becomes a chip-based device...
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    Fluorescence

    ADVANCED MICROSCOPY/SUPERCONTINUUM WHITE LIGHT: Multiple microscopy modes in a single sweep with supercontinuum white light

    May 1, 2013
    Lasers have been critical to the advancement on confocal microscopy, and the white light laser (WLL) offers particular advantages. Finessing WLL output for bioimaging is a complex...

    More content from Volume 6, Issue 3

    (Image courtesy of Mightex Systems)
    FIGURE 1. Mightex offers its BioLED Control Module and a multi-wavelength fiber-coupled LED—both designed for optogenetics.
    Neuroscience

    OPTOGENETICS/NEUROSCIENCE: Optogenetics tools address a growing range of applications

    May 1, 2013
    A combination of optical and genetic technologies, optogenetics inspires the imagination. It has already made a mark in basic research, and its lab impact will grow. But clinical...
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    Fluorescence

    PHOTOACOUSTICS/MICROSCOPY: With interdisciplinary approach, BioPIC promotes excellence

    May 1, 2013
    Designed as a multidisciplinary showcase of advances in light-based imaging technologies and their potential application to biology and medicine, the BioPIC 2013 international...
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    Microscopy

    HANDHELD BIOPHOTONICS: Biophotonics is growing, no matter how the market is defined

    May 1, 2013
    An industry report released in April 2013, Biophotonics Market: Technologies and Market Analysis, acknowledges that the size of the biophotonics market and its growth rate depend...
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    Fluorescence

    INTRACELLULAR IMAGING/FLUORESCENCE MICROSCOPY: Cycled quantum-dot approach boosts capabilities for single-cell molecular profiling

    May 1, 2013
    A simple, low-cost method for color-coding individual cells can illuminate 10 times as many biomarkers as is otherwise possible—and thus promises to allow more comprehensive analysis...
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    Biomedicine

    ONCOLOGY/CANCER TREATMENT: Study reveals potential of terahertz pulses to fight cancer

    May 1, 2013
    Terahertz (THz) photons don't have sufficient energy to break apart the bonds that bind DNA in a cell's nucleus.
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    Fluorescence

    CANCER DETECTION/FLUORESCENCE: Point-of-care microRNA detector can yield early-stage cancer diagnosis from a single drop of blood

    May 1, 2013
    With sufficient concentrations of a target, the "most sensitive microRNA detector yet" can analyze a drop of blood for cancer-specific biomarkers called microRNAs in just 20 minutes...
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    Biomedicine

    OPTOACOUSTICS/OXIMETRY: Real-time photoacoustics beats pulse oximetry by measuring oxygenation in single cells

    May 1, 2013
    Red blood cells ferry oxygen to a body's cells and tissues by way of arteries, veins, and capillaries.
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    Fluorescence

    HIGH-RESOLUTION MICROSCOPY/FLUORESCENCE IMAGING: Super-sensitive fluorophore facilitates cost-effective two-photon imaging

    May 1, 2013
    A new dye could reduce the cost of two-photon microscopy (TPM) by several orders of magnitude, according to researchers who developed it.
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    Spectroscopy

    SPECTROSCOPY/ONCOLOGY/GYNECOLOGY: First-ever minimally invasive ovarian cancer screen is spectroscopy-based

    May 1, 2013
    Researchers at Northwestern University and NorthShore University HealthSystem have previously demonstrated the ability of partial-wave spectroscopy to detect subtle changes in...
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    Neuroscience

    OPTOGENETICS/NEUROSCIENCE: Light-triggering brain study shows biological basis for cocaine addiction

    May 1, 2013
    Strategic use of laser light can turn addictive behavior on and off in rats, according to research conducted at the NIH and the UCSF.
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    Biophotonics Tools

    DEEP TISSUE IMAGING/TERAHERTZ TECHNOLOGY: Powerful laser-based terahertz system promises unprecedented depth for tissue imaging

    May 1, 2013
    A laser-powered terahertz (THz) source and detector system transmits with 50 times more power, and receives with 30 times greater sensitivity, than existing technologies, according...