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  • Volume 8, Issue 1
  • Volume 8, Issue 1

    (Photo credit: Lars Kruse, Aarhus University)
    PhD student Joana Guerreiro has taken part in developing an optical biosensor that measures how we experience the feeling of dryness in wine.
    Spectroscopy

    Optical biosensor for winemaking has potential for drug development

    Jan. 21, 2015
    A novel optical biosensor developed by researchers at the Interdisciplinary Nanoscience Centre (iNANO) of Aarhus University in Denmark could help winemakers control the level ...
    1501end Fig2
    Microscopy

    Light microscopy award winners depict life's magic

    Jan. 21, 2015
    The annual Olympus BioScapes Digital Imaging Competition honors still and moving images of human, plant, and animal subjects as captured through light microscopes.
    1411bow15 13077 Walt014
    Fluorescence

    BIOPHOTONICS: Collaboration is key to success in biophotonics

    Jan. 21, 2015
    In an interview, biophotonics pioneer David Walt discusses his thoughts on education, entrepreneurship, and the future of photonics technologies for life sciences.
    Dragon Green beads imaged with a 10x/0.3NA Nikon CFI Plan Fluor objective (left column), and the same beads imaged with a 10/x0.5NA Nikon Super Fluor objective (right column).
    Fluorescence

    FLUORESCENCE MICROSCOPY/QUANTITATIVE IMAGING: A systems-engineering approach to quantitative fluorescence bioimaging

    Jan. 21, 2015
    Fluorescence microscopy can detect concentrations of important biomarkers that are barely visible. Learn the three factors that influence the quality of quantitative fluorescence...
    FIGURE 1. The original Sanger sequencing method was based on terminated polymerizations and labeling with radioactive nucleotides followed by length separation using electrophoresis on gel plates. It was modified to use fluorescent nucleotides, capillary electrophoresis separation, and laser detection, enabling first-generation automation.
    Fluorescence

    GENETICS/DNA SEQUENCING: Laser fluorescence powers sequencing advances

    Jan. 21, 2015
    DNA sequencing based on laser-excited fluorescence is characterized by dramatic increases in throughput, equally impressive reductions in cost, and diverse technological innovations...

    More content from Volume 8, Issue 1

    FIGURE 1. A collection of fluorophores, excited by a short optical pulse (thick line), produces collective fluorescence emission that follows an exponential decay curve with 1/e lifetime τ (a). Regardless of the intensity of the excitation pulse, the decays from identical fluorophores all have the same characteristic lifetime τ (b).
    Fluorescence

    CELL BIOLOGY/FLOW CYTOMETRY: Instrumentation advances add flexibility and quantitation to flow cytometry

    Jan. 20, 2015
    Despite its usefulness for bioimaging, fluorescence tagging has critical limitations. But a variant called fluorescence lifetime inherently solves longstanding problems and offers...
    (Image courtesy of Frank Vollmer)
    FIGURE 1. This photonic microsystem (a) can detect single DNA molecules, which appear as spikes in the sensor signal (b).
    Fluorescence

    SINGLE-MOLECULE DETECTION: Detecting single molecules

    Jan. 20, 2015
    Biophotonics aids in the ultimate quest to understand how our bodies work, as scientists create increasingly capable optical systems and techniques to track the molecular components...
    Kendall Research's FireFly is a complete system for wireless optical neuromodulation.
    Fluorescence

    MICROSCOPY/OPTOGENETICS: Neuroscience 2014 emphasizes instrumentation

    Jan. 20, 2015
    Technology was a focus at Neuroscience 2014 (November 15-19; Washington, DC), where in past years the tools behind the developments have been difficult to discern.
    As graduate student Sabrina Grech (center) describes work in laser tissue welding, Senior Associate Researcher Stephane Lubicz, MD (right), describes the operation of instrumentation used for the work. Yisa Rumala, Ph.D. (left), who is part of the supercontinuum team at CCNY, served as a tour guide during the event.
    Microscopy

    BIOMEDICAL IMAGING, TREATMENT, AND RESEARCH: CCNY celebrates advances in biomedical optics

    Jan. 20, 2015
    The Advances in Biomedical Optics and Photonics event (November 12, 2014) held at The City College of the City University of New York (New York, NY) included a tour of the Institute...
    A display called Larger Than Life lined corridors of the Philadelphia airport with large-scale cell images created by researchers from the local area.
    Fluorescence

    CELL BIOLOGY/LIVE CELL IMAGING: Cell Bio extols optical methods

    Jan. 20, 2015
    Visitors flying in to Philadelphia, PA for the 2014 American Society for Cell Biology Annual Meeting (December 6-10) began their cell-bio immersion at the airport, where a display...
    1501bowbreak Fig4
    Bioimaging

    PHOTODYNAMIC THERAPY: Molecular disguises allow in vivo light activation of signaling peptides

    Jan. 20, 2015
    Scientists have demonstrated the use of disguises to sneak biomaterials containing peptide-signaling molecules into the bodies of living animals.
    1501bowbreakf3
    Biomedicine

    PHOTODYNAMIC THERAPY: Photoswitchable drug may increase safety of type 2 diabetes treatment

    Jan. 20, 2015
    Type 2 diabetes mellitus affects 1 in 12 adults worldwide, and a class of drugs called sulfonylureas are a mainstay of diabetes therapy.
    A 3D-printed smartphone add-on images and measures single-molecule DNA strands.
    Fluorescence

    SINGLE-MOLECULE MICROSCOPY/PORTABLE PATHOLOGY: Compact devices compete with high-end instruments

    Jan. 20, 2015
    One compact device converts an ordinary smartphone into a fluorescence microscope capable of single-molecule detection and measurement, while another uses holography to do the...
    Barbaragoode2
    Fluorescence

    ...and light-based technologies

    Jan. 20, 2015
    That's right, 2015 is the International Year of Light and Light-based Technologies—as proclaimed by The United Nations (UN) General Assembly 68th Session more than a year ago....