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    (Courtesy of Andrey Andreev)
    Fixed-wavelength ultrafast lasers (left) and power supplies (right) are more compact than their tunable Ti:sapphire alternatives (fixed-wavelength laser and power supply are orange; tunable are blue-green). However, for two-photon microscopy, each laser technology has its advantages and disadvantages that the researcher must carefully consider.
    Lasers & Sources

    Two-photon microscopy and the $100,000 question: tunable or fixed-wavelength femtosecond laser?

    Nov. 17, 2020
    Many biologists are unfamiliar with ultrafast laser technology, but still need to decide between tunable or fixed-wavelength lasers for their two-photon microscopy applications...
    Kinetic River Potomac Flow Cytometer
    Biophotonics Techniques

    Kinetic River delivers custom flow cytometer to National Research Council

    Nov. 9, 2020
    The customized flow cytometer was installed at the National Research Council in Naples, Italy for biomedical research and water monitoring.
    Trapped Biotin 50538602892 O Cropped
    Biophotonics Techniques

    X-ray crystallography could improve widely used molecular pairing

    Oct. 28, 2020
    By creating new ways to control the binding and release of the two molecules, many new lab techniques can now be developed to enable new health discoveries and improved diagnostic...
    FIGURE 1. In SCAPE, a light sheet is formed at an oblique angle by off-axis illumination of the primary microscope objective with a line profile beam (a); SCAPE builds a volumetric image by scanning the light sheet while capturing a series of images of the illuminated plane (b).
    Detectors & Imaging

    High-resolution, multicolor 3D imaging at the speed of life

    Dan Callen
    Oct. 13, 2020
    An innovative laser fluorescence technique, swept confocally aligned planar excitation (SCAPE) microscopy, overcomes the limitations of earlier methods and offers broad life sciences...
    (Courtesy of Madatec Srl, Milan, Italy)
    FIGURE 1. Reflectance spectra of Prussian blue (blue), synthetic lapis lazuli (green), and synthetic azurite (purple).
    Spectroscopy

    Spectroscopy uncovers the hidden in art and archaeology

    Robert V. Chimenti
    Oct. 13, 2020
    Art conservation, cultural heritage, and archaeological studies are key applications for numerous forms of spectroscopy.

    Recommended

    2010 Lfw Ia Hero
    Home

    Laser Focus World announces 2020 Innovators Awards

    John Lewis
    Oct. 13, 2020
    For the third straight year, Laser Focus World held its Innovators Awards program, which celebrates the disparate and innovative technologies, products, and systems found in the...
    Spectral angle mapping (SAM) allowed differentiation of cells imaged using hyperspectral dark-field microscopy. Cells below the threshold spectral angle are marked as positive using a green outline; cells above the threshold are marked as negative with a red outline. Isolate cell detection shows positive E. coli 157:H7 (a) and Listeria monocytogenes (b). A slide with both pathogens depict E. coli (c) at positive (48) and negative (65), and Listeria monocytogenes (d) at positive (66) and negative (47).
    Detectors & Imaging

    Pathogen detection with hyperspectral dark-field microscopy

    Alexandre Fong
    July 14, 2020
    Aided by deep learning, hyperspectral imaging facilitates high-speed single-cell pathogen detection with no critical volume and little prep.
    The proof-of-principle hardware shown here has been converted into a compact, noninvasive device to precisely measure eye movements and correlate them with the severity of neurological disease.
    Detectors & Imaging

    Linking retinal function to brain disease

    Richard Gaughan
    July 14, 2020
    Video images from a reflected-light laser scan of the human retina characterize small eye movements to monitor the severity of multiple sclerosis.
    Ingaas
    Test & Measurement

    Axiom Optics laser beam profiler has use in lab and production settings

    July 4, 2020
    The CinCam InGaAs laser beam profiling system can characterize beams within ISO standards in the 900 to 1800 nm range.
    FIGURE 1. Imaging Mass Cytometry (IMC) begins with the user loading a slide prepared with an antibody-stained specimen into the Hyperion Imaging System and using system controls to select a region of interest to be imaged (a). The system’s pulsed laser, operating at 213 nm, enables precise imaging: The beam, focused at 1 µm diameter, samples proteins stained with metal-tagged antibodies and directs these tags to analysis by inductively coupled time-of-flight (ToF) technology. This occurs in a single scan as the laser samples each squared-micron pixel in the selected region (b).
    Test & Measurement

    Tumor architecture insights advance cancer diagnosis and treatment

    June 16, 2020
    The integration of novel laser ablation and mass cytometry enables spatial resolution of single-cell phenotypes, promising a new advance for cancer diagnostics and therapy.