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  • Volume 3, Issue 6
  • Volume 3, Issue 6

    FIGURE 1. A Raman spectrum of cholesterol delineates the fingerprint and high wavenumber Raman shift regions. If the spectrum of the excitation light were included, it would be on the far-left side of the plot and would be several orders of magnitude larger than this spectrum.
    Biophotonics Tools

    BIOSPECTROSCOPY/CARDIOLOGY: High-wavenumber Raman reveals composition and location of intracoronary plaques

    Nov. 1, 2010
    Catheters based on advanced high-wavenumber Raman spectroscopy can identify and quantify lipids and lipid subcategories within human coronary arteries in-vivo. The technology ...
    Using excitation emission matrix spectroscopy, researchers have discovered the unique spectral fingerprints for oil, weathered oil, and dissolved oil from the Deepwater Horizon oil spill in the Gulf of Mexico. Ongoing fluorescence studies will assist in development of new optical sensors to track oil in seawater.
    Fluorescence

    ASSESSMENT/FLUORESCENCE/SPECTROSCOPY: Optical technologies aid oil spill efforts, with boost from NSF

    Nov. 1, 2010
    As oil gushed into the Gulf of Mexico this summer, the National Science Foundation (NSF) responded with lightning speed to fund proposals for research related to the spill.
    (Image courtesy Jun Zhang and Zhongping Chen)
    FIGURE 1. The fiber-optic probe (left) is small enough to enable intra-oral imaging (center), and the display makes easily visible the output of the probe (right).
    Fluorescence

    OPTICAL DIAGNOSTICS/ONCOLOGY: Practical, sensitive and specific: Applying OCT for oral cancer screening

    Nov. 1, 2010
    Today's most common oral cancer diagnostic method is prone to false positives and negatives. Optical technologies promise non-invasive, non-ionizing solutions, however, and in...
    (Image courtesy of Philipp J. Keller)
    FIGURE 1. Using DSLM-SI, cells in a fly embryo can be reconstructed. These orthographic renderings come from data at 3.20 and 4.85 hours post-fertilization (left and right, respectively). Each sphere corresponds to one nucleus, with the color encoding the average local nuclear movement speed (cyan to orange: 0-0.8 µm/min).
    Fluorescence

    INSIDE INSTRUMENTATION: Bringing structured illumination microscopy to the masses

    Nov. 1, 2010
    One of the most recent approaches to making a three-dimensional representation from two-dimensional imagery comes from structured illumination microscopy (SIM).
    7421
    Neuroscience

    BIOPHOTONICS TECHNOLOGY ROADMAPPING: Branding, front-line involvement, and funding were themes at bio-optics congress

    Nov. 1, 2010
    Biophotonics Week in September brought together approximately 300 people for two conferences, a workshop, and a graduate school.

    More content from Volume 3, Issue 6

    69728
    Fluorescence

    Components Systems & Products

    Nov. 1, 2010
    The Spectral Reflectance Imaging Biosensor (SRIB) is a multiplexed immunoassay platform that identifies specific protein biomarkers in blood, urine or saliva, and enables many...
    62445
    Microscopy

    Rainbow of variously shaped nanoparticles promising for live-cell studies

    Nov. 1, 2010
    A simple synthesis method, developed by X. Nancy Xu and her research group AT Old Dominion University (ODU), is able to produce silver and gold nanoparticles in an array of shapes...
    16815
    Fluorescence

    Synchronized laser therapy gets people back on the right foot quickly

    Nov. 1, 2010
    Ed Davis, DPM, FACFAS, a podiatrist based in the San Antonio, TX, area, has boosted his treatment options in his practice with Multiwave Locked System (MLS) therapy for treating...
    41164
    Cell Biology

    Photostimulation may help get to the heart of cardiac arrest recovery

    Nov. 1, 2010
    Scientists at the University of Bonn (Germany) have succeeded in altering cardiac muscle cells to make them controllable with light, and then causing conditions such as arrhythmia...
    FIGURE 1. Topical PDT is administered using an Aktilite 128 LED source (Photocure ASA/Galderma), which has a field large enough to enable treatment of one whole lower leg surface in one sitting (right). The Aktilite 16 is the same lamp with a smaller irradiation field, and therefore it is suitable only for single lesions (left).
    Fluorescence

    DERMATOLOGY/PHOTODYNAMIC THERAPY: The benefits of topical photodynamic therapy in dermatology

    Nov. 1, 2010
    Topical photodynamic therapy (PDT) has been increasingly used in recent years, and its main indication is for superficial non-melanoma skin cancer. This approach can offer several...
    36763
    Fluorescence

    Fluorescence approach overcomes obstacles to probe seafood for safety

    Nov. 1, 2010
    A fluorescent probe developed at the University of California at San Diego could enable real-time toxin screening of seafood.
    6392
    Biophotonics Tools

    LEDs enable fast, high-resolution multispectral eye imaging for disease screening

    Nov. 1, 2010
    A new imaging system that uses six different wavelengths to illuminate the eye's interior (ocular fundus) may pave the way for doctors to easily screen patients for common diseases...
    59934
    Biomedicine

    Nanoparticles enter cell nuclei and report back via spectroscopy

    Nov. 1, 2010
    Hitching a ride on an HIV protein known for its ability to penetrate human cells, silver nanoparticles have proven able to enter cell nuclei and report on their surroundings using...
    11575
    Spectroscopy

    SERS-based microfluidic chip distinguishes bacteria

    Nov. 1, 2010
    Engineers at Taiwan's National Cheng Kung University have created an on-chip method for sorting and identifying bacteria.
    13606
    Spectroscopy

    Revved-up broadband CARS maps biomolecules fast, without damage

    Nov. 1, 2010
    Broadband coherent anti-Stokes Raman scattering (B-CARS) has typically been considered unusable for bioimaging.